Injectables

Xeomin® (incobotulinumtoxinA) is a prescription medication injected into muscles and used to temporarily improve the appearance of moderate to severe frown lines between the eyebrows (glabellar lines) in adults. Xeomin® contains botulinum toxin type A, a protein purified from the bacterium Clostridium botulinum.

When you squint or frown, the muscles between your eyebrows contract, causing the skin to furrow and fold. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines. Botulinum toxin type A – the active ingredient in Xeomin®– acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, Xeomin® can temporarily reduce the lines between your eyebrows.

During treatment, which usually takes about 10-20 minutes, your doctor will inject Xeomin® into the muscles in your forehead that cause frown lines between your eyebrows. No anesthesia is required; however, your physician may use a topical anesthetic or cold pack to reduce any discomfort.

You may begin to see visible smoothing as early as 3-4 days after injection. The median first onset of effect was less than a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.

BOTOX® Cosmetic is a prescription medicine that is injected into muscles and used to improve the look of moderate-to-severe frown lines between the brows in people 18 to 65 years of age for a short period of time (temporary). BOTOX® Cosmetic is administered by a healthcare professional as a simple, nonsurgical treatment that is injected directly into the muscles between the brows. It works by blocking nerve impulses to the injected muscles. This reduces muscle activity that causes moderate to severe lines to form between the brows.

BOTOX® Cosmetic, introduced in 2002, is the first botulinum toxin to be approved by the FDA to temporarily treat moderate to severe glabellar lines between the brows. With real, noticeable results, no surgery and no recovery time, there are many reasons why BOTOX® Cosmetic has been chosen by millions of women and their doctors. Approximately 11.8 million BOTOX® Cosmetic procedures have been administered in the United States since 2002. 92% of 303 patients surveyed were satisfied with the results of their BOTOX® Cosmetic experience. Individual results may vary.

• BOTOX® or BOTOX® Cosmetic is an injection that your doctor will give you.

• BOTOX® is injected into your affected muscles or skin.

• BOTOX® Cosmetic is injected into your affected muscles.

• Your doctor may change your dose of BOTOX® or BOTOX® Cosmetic, until you and your doctor find the best dose for you.

• Those who have had an allergic reaction to any other botulinum toxin product such as Myobloc® or Dysport®

• Those who have a skin infection at the planned injection site

Tell your doctor about all of your medical conditions, including if you have:

• A disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig’s disease], myasthenia gravis or Lambert-Eaton syndrome)

• Allergies to any botulinum toxin product

• Had any side effect from any botulinum toxin product in the past

• A breathing problem, such as asthma or emphysema

• Swallowing problems

• Bleeding problems

• Plans to have surgery

• Had surgery on your face

• Weakness of your forehead muscles, such as trouble raising your eyebrows

• Drooping eyelids

• Any other change in the way your face normally looks

• Are pregnant or plan to become pregnant. It is not known if BOTOX® or BOTOX® Cosmetic can harm your unborn baby.

• Are breast-feeding or plan to breastfeed. It is not known if BOTOX® or BOTOX® Cosmetic passes into breast milk.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines and/or vitamins and herbal products. Using BOTOX® or BOTOX® Cosmetic with certain kinds of medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received BOTOX® or BOTOX® Cosmetic in the past. Especially tell your doctor if you:

• Have received any other botulinum toxin product in the last four months

• Have received injections of botulinum toxin, such as Myobloc® (rimabotulinumtoxinB) or Dysport® (abobotulinumtoxinA) in the past. Be sure your doctor knows exactly which product you received.

• Have recently received an antibiotic by injection

• Take muscle relaxants

• Take an allergy or cold medicine

• Take a sleep medicine

Ask your doctor if you are not sure if your medicine is one that is listed above. Know the medicines you take. Keep a list of your medicines with you to show your doctor and pharmacist each time you get a new medicine.

BOTOX® Cosmetic may cause loss of strength or general muscle weakness or vision problems within hours to weeks of taking BOTOX® or BOTOX® Cosmetic. If this happens, do not drive a car, operate machinery or do other dangerous activities. See: What is the most important information I should know about BOTOX® and BOTOX® Cosmetic?